bacB [2017-8-11 16:0:3]

oxidase that catalyzes the synthesis of 2-oxo-3-(4-oxocyclohexa-2,5-dienyl)propanoic acid, a precursor to L-anticapsin

Locus: BSU37730

Isoelectric point: 5.19

Molecular weight: 26.69 kDa

Protein length: 235 aa

Gene length: 705 bp

Function: biosynthesis of the antibiotic bacilysin

Product: oxidase

Essential: no

Synonyms: ywfC, ipa-81d

Genomic Context

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Categories containing this gene/protein

• Metabolism → Additional metabolic pathways → Miscellaneous metabolic pathways → Biosynthesis of antibacterial compounds
• Lifestyles → Coping with stress → Biosynthesis of antibacterial compounds

Gene

Coordinates: 3,872,869 → 3,873,576

The protein

Catalyzed reaction/ biological activity

• synthesis of 2-oxo-3-(4-oxocyclohexa-2,5-dienyl)propanoic acid, a precursor to L-anticapsin PubMed

Structure

• 3H7J PubMed

Expression and Regulation

Operons

• Genes: bacA-bacB-bacC-bacD-bacE-bacF
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • CodY: repression, PubMed, in CodY regulon
  • AbrB: repression, PubMed, in AbrB regulon
  • ScoC: repression, PubMed, in ScoC regulon

  Regulation

  • expression of the operon is strongly induced at the beginning of biofilm formation PubMed

Biological materials

Mutant

• MGNA-B240 (ywfC::erm), available at the NBRP B. subtilis, Japan

References

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